B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial
"Historical episodes of air pollution peaks were shown to be associated with up to >10 times increased death rates. According to the WHO, 92% of the world’s population currently lives in places where air quality levels exceed the WHO limits."
"B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial" source
"Ambient PM2.5 (particles with an aerodynamic diameter of <2.5 µm) pollution is one of the most prominent air pollutants, because they deposit in the respiratory bronchioles and the alveoli and stimulate local and systemic inflammation and oxidative stress. Over the past few decades, substantial lowering of ambient PM2.5 levels has been achieved through large-scale emissions control policies. However, exposure peaks with adverse health consequences are still frequently recorded, even in areas typically exhibiting low levels. The molecular mechanisms underlying PM2.5’s health effects are not fully understood, and the lack of preventative options at the individual level adds complexity to tackling this major public health challenge.
Recent studies in environmental epigenetics provide opportunities to understand the mechanistic underpinnings of exposure-related health effects and to develop novel individual-level interventions. DNA methylation, a potentially modifiable epigenetic mechanism, can regulate gene expression and chromosome integrity via addition of methyl groups to cytosine residues."
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